Neonatal binge alcohol exposure increases microglial activation in the developing rat hippocampus
نویسندگان
چکیده
منابع مشابه
Binge ethanol exposure decreases neurogenesis in adult rat hippocampus.
Alcoholism is associated with cognitive deficits and loss of brain mass. Recent studies have indicated that neural progenitor cells proliferate throughout life forming neurons, astrocytes, and oligodendrocytes. The dentate gyrus is one neurogenic region of the adult brain containing neural progenitor cells. To determine if binge ethanol (EtOH) exposure alters neural progenitor cell proliferatio...
متن کاملMicroglial Activation in Rat Experimental Spinal Cord Injury Model
Background: The present study was designed to evaluate the secondary microglial activation processes after spinal cord injury (SCI). Methods: A quantitative histological study was performed to determine ED-1 positive cells, glial cell density, and cavitation size in untreated SCI rats at days 1, 2, and 4, and weeks 1, 2, 3, and 4. Results: The results of glial cell quantification along the 4900...
متن کاملPrior Binge Ethanol Exposure Potentiates the Microglial Response in a Model of Alcohol-Induced Neurodegeneration
Excessive alcohol consumption results in neurodegeneration which some hypothesize is caused by neuroinflammation. One characteristic of neuroinflammation is microglial activation, but it is now well accepted that microglial activation may be pro- or anti-inflammatory. Recent work indicates that the Majchrowicz model of alcohol-induced neurodegeneration results in anti-inflammatory microglia, wh...
متن کاملChronic neonatal nicotine exposure increases excitation in the young adult rat hippocampus in a sex-dependent manner.
Smoking during pregnancy exposes the fetus to nicotine, resulting in nicotine-stimulated neurotransmitter release. Recent evidence suggests that the hippocampus develops differently in males and females with delayed maturation in males. We show that chronic nicotine exposure during the first postnatal week has sex-specific long-term effects. Neonatal rat pups were chronically treated with nicot...
متن کاملEffect of morphine exposure on developing rat hippocampus
INTRODUCTION Opioid are used in the neonatal intensive care unit (NICU) for pain management and sedation of infants requiring mechanical ventilation [1]. Adult rats exposed to recurrent administration of opioids in the absence of pain have decreased neurogenesis and altered neurotransmitters in the dentate gyrus of the hippocampus [2, 3]. Prenatal exposure to opioids causes long-term learning a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neuroscience
سال: 2016
ISSN: 0306-4522
DOI: 10.1016/j.neuroscience.2016.03.033